Epidemiology Seminar Series - Luciana Macchion Shaddox

Nov 21, 2019 to Nov 21, 2019


"Agressive Periodontitis in Children and Adolescents"

Periodontal disease is an inflammatory process affecting the protective and supportive tissues around the tooth. When this disease is rapidly progressing early in life, it is called aggressive periodontitis, more recently Grade C (high risk of pregression) periodontitis. The aggressive for of this disease starts early in life, is found in less than 3% of the population in North America, differently than the more common slowly progressive form of periodontitis, which affects 1 out of 2 Americans, and most commonly African-Americans. It is known to aggregate in families. When the disease starts, it affects very specific teeth in the mouth, permanent or primary (baby) teeth, leading to a rapid bone destruction if not treated timely. Treatment of the disease involves removal of bacterial deposits and systemic antibiotics. However, it is not clear in the literature when during therapy antibiotic therapy should be prescribed and which type and maintenance of the disease is essential to prevent its recurrence. We have studied a population with this disease for over ten years now in the attempt to unveil this disease etiology, contributing factors and response to treatment. In this lecture, we will cover aspects of localized aggressive periodontitis clinical presentation, etiopathogenesis, risk factors and treatment responses.


Luciana Macchion Shaddox, DDS, MS, Ph.D.

Professor and Associate Dean of Research

Division of Periodontology

Department of Oral Health Practice

University of Kentucky College of Dentistry



Dr.Luciana Shaddox has recently joined the University of Kentucky Division of Periodontology as a professor with tenure as of July 2018. She obtained her DDS, MS at University of Campinas, Brazil and part of her PhD was developed in conjunction with University of Florida Oral Biology department in 2004. She completed a one year pos-doctoral fellowship in Periodontal Microbiology at UF before joining UF Periodontology as faculty full-time in 2006. She became an associate professor with tenure at UF in 2012 and promoted to full professor in 2018 right before joining UK Dentistry.


Currently at UK, she is the director of research for the Periodontology graduate program, directs of one of the Periodontology courses for DMD students at UK, participates in several college and national committees and has an intense clinical translational research program supported by NIH since 2009. Her main research focus is aimed at evaluating immunological, microbiological and genetic factors involved with localized aggressive periodontal disease in children and adolescents. She has over 60 publications in peer-reviewed journals, she has been an ad-hoc member of several NIH study sections since 2016 and is the recipient of several research student-mentored awards and personal awards, including the prestigious American Academy of Periodontology Teaching Fellowship Award and the University of Florida Professorship Award.