This project will establish the Rapid Actionable Data for Opioid Response in Kentucky (RADOR-KY), an integrated, population-based, statewide system that will ingest data from multiple state agencies and implement advanced informatics algorithms for fast data processing, data linkage, machine learning and predictive analytics to shorten the time between data capture and when analytical results are available to support opioid and other drug overdose prevention and control. RADOR-KY End-User Advisory Group, including partners in state government and local communities, will guide the development of the reporting and visualization functionality.